After 30 years of building engines (cars, motorcycles, and even aviation related engines) it's my opinion that the "run it hard" method provides the best break-in and longevity for an engine. Understand, this does not mean just run the heck out of it. There is a proper procedure for doing it.
In fact, in the aviation world, this is the method used. I don't know too many people that will argue that engine reliability and performance are not paramount factors in aviation, for obvious reasons.
If you doubt this, then you can check for yourself by reading this article on Cessna Aircraft's site:
http://www.cessna.org/benefits/articles/breakin.htmlThe science behind this method is sound and proven.
Keep in mind that a proper break-in is not just about seating the rings for performance. The prevention of blow-by is important as contaminants quickly degrade engine oil, seriously reducing engine life.
The use of synthetics for break-in is indeed a bad idea. The lubricity of synthetics does not allow the initial desired friction and wear to occur as well as petroleum based oils do, thus extending the break-in period and garnering the associated issues with it.
Glazing of the cylinder walls is a common problem when engines are broken in according to the owner's manual (i.e. "babied"). I've seen it too many times first hand.
Modern metallurgy and machining accuracy has indeed changed the break-in procedures, but these changes have only manifested themselves primarily in terms of the time it takes and the level of precision the break-in can achieve. The basic science of why it is done has not changed.
Modern technological advances in cylinders (nikasil, ceramic linings, etc) have allowed engine break-ins to occur in very short periods of time (some in as little as 1 hour). The reason is how these linings retain oil on the cylinder wall, how fine their finish is, etc (porous vs peak and valley scratches of honed steel). However, the science and mechanics of why and how to brak-in are no different.
The more perfect the seal of ring to cylinder, the better the engine performs and the longer it lasts. The only way to achieve this kind of fit between two metal objects is to rub them together and allow them to wear into each other. Due to heat and contaminants and their effects on oil, the faster you can conclude this break-in, the better.